吴明

预防保健与医院感染管理部

主任

硕士生导师、博士后合作导师

PI介绍

       深圳市第二人民医院(深圳市转化医学研究院)预防保健与医院感染管理部主任,医学博士,硕士研究生导师、博士后合作导师。主要从事脓毒症、严重创伤、ARDS、AKI、SAP、MODS等的临床救治20余年,熟练掌握了重症超声、纤维支气管镜肺泡灌洗、血浆净化及ECMO等技术。擅长危重病救治及多重耐药菌感染的综合防治。在脓毒症、重症凝血、AKI、CRRT、MODS基础及临床研究方面有较深的理解。

      现任中国康复医学会重症康复专业委员会生命支持学组常委、中国研究型医院学会血栓与止血分会委员、中国医药教育协会血栓与止血危重病专业委员会委员、广东省临床医学学会血浆治疗专业委员会常委、广东省病理生理学会危重病专业委员会委员、深圳市医学会重症医学专业委员会副主任委员、深圳市健康管理学会血液净化专业委员会副主任委员等。现为深圳大学、汕头大学医学院、广东医科大学、广西中医药大学等高校硕士研究生导师,已招收全日制硕士研究生5人;近5年来主持省、市院级基金6项,发表学术论文50余篇,其中以第一或通讯作者发表SCI文章20篇,申请国家发明专利2项、实用新型专利2项,获得国家发明专利及实用新型专利各1项,现为European Journal of Internal Medicine、Kidney and Blood Pressure Research、Platelets、Renal Failure、frontiers in medicine等杂志审稿人。

科研项目

1.  深圳市科技创新委员会,面上项目,JCYJ20190806163603504,Caveolin-1调控内质网应激影响肾小管铁死亡在重症中暑肾损伤中的机制研究,2020-08至2023-07,10万元,在研,主持;

2. 深圳市科技创新委员会,面上项目,JCYJ20170306091335008,黄芩素调控巨噬细胞线粒体自噬对脓毒症小鼠肾小管焦亡影响的实验研究,2017-05至2020-05,25万元,已结题,主持;

3. 广东省高水平医院建设--深圳市第二人民医院,临床研究项目,20193357003,肾血流阻力指数在预测脓毒症急性肾损伤价值的临床研究,2019-07至2022-06,30万元,在研,主持;

4. 广东省高水平医院建设--深圳市第二人民医院,临床研究项目,20203357014,黄连素治疗脓毒症合并急性胃肠损失的单中心随机双盲对照试验,2020-07至2023-06,15万元,在研,主持;

5. 深圳市卫生健康委,临床研究项目,SZLY2017007,连续血液滤过吸附联合血浆置换治疗脓毒症合并MODS的RCT研究,2017-06至2020-05,30万元,结题,主持。

代表性成果

1.Li Zhong#, Yan Liu#, Conglin Wang, Zheying Liu, Lei su*, Zhifeng Liu*, Ming Wu*. Association of persistent thrombocytopenia with unfavorable outcomes in patients with exertional heatstroke: an over 10-year intensive care survey in southern China. Annals of medicine2024,56(1)(中国科学院二区,IF:4.9)

2.Yongsen Tan#, Jiahui Huang#, Jinhu Zhuang, Haofan Huang, Mu Tian, Yong Liu, Ming Wu*, Xiaxia Yu*. Fine-grained subphenotypes in acute kidney injury populations based on deep clustering: derivation and interpretation. Int J Med Inform. 2024 :191:105553.(中国科学院二区,IF:3.7)

3.Zhipeng Zhou#, Li Zhong#, Yan Liu#, Zhenjia Yang, Jiajia Huang, Dazheng Li, Yu-hua Chen, Zhiye Zou, Yingyi Luan*, Yongming Yao*, Ming Wu*. Impact of early heparin therapy on mortality in critically ill patients with sepsis-induced acute kidney injury: A retrospective study from the MIMIC-IV database. Front. Pharmacol, 2024, 14:1261305.(中国科学院二区,IF:4.4)

4.Jia-jia Huang#, Zhi-ye Zou#, Zhi-peng Zhou,Yan Liu, Zhen-jia Yang, Jing-jing Zhang, Ying-yi Luan, Yong-ming Yao*, Ming Wu*. Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy. Front. Pharmacol. 2023, 14:1173893.(中国科学院二区,IF:4.4)

5.Ying-yi Luan#, En-ping Huang#, Jia-jia Huang, Zhen-jia Yan, Zhi-peng Zhou,Yan Liu, Ming Wu*, Serum myoglobin modulates kidney injury via inducing ferroptosis after heatstroke. J Transl Int Med, 2023, 11(2):178-188. (中国科学院二区,IF4.7

6.Zhi-ye Zou#, Jia-jia Huang#, Ying-yi Luan#, Zhen-jia Yang, Zhi-peng Zhou, Jing-jing Zhang, Yong-ming Yao*, Ming Wu*. Early prophylactic anticoagulation with heparin alleviates mortality in critically ill patients with sepsis: A retrospective analysis from the MIMIC-IV database. Burns & trauma, 2022,10,tkac029.(中国科学院一区,IF: 6.3)

7.Zhi-ye Zou#, Kai-jun Sun#, Guang Fu, Jia-jia Huang, Zhen-jia Yang, Zhi-peng Zhou, Shao-lin Ma*, Feng Zhu*, Ming Wu*. Impact of early empirical antifungal therapy on prognosis in sepsis patients with positive yeast culture: a retrospective study based on the MIMIC-IV database. Front Microbiol.2022,13:1047889.(中国科学院二区,IF:4.0)

8.Chuang Yuan, Ming Wu, Qicai Xiao, Wang Zhao, Hongli Li, Yanjun Zhong, Minyi Zhao, Cheng Li, Yang Li, Xinyu Yang*. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis. Signal Transduction and Targeted Therapy, 2021,6:92(中国科学院一区,IF40.8)

9.Ziyun Shao#, Yongwen Feng#; Li Zhong#; Qifeng Xie#; Ming Lei#; Zheying Liu; Conglin Wang; Jingjing Ji; Huiheng Liu; Zhengtao Gu; Zhongwei Hu*, Lei Su*, Ming Wu*, Zhifeng Liu*. Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID-19: a multicenter retrospective cohort study. Clinical & Translational Immunology, 2020, 9(e1192)(中国科学院二区,IF4.6)

10.Ming Wu#, Jing-jing Ji#, Li Zhong, Zi-yun Shao, Qi-feng Xie, Zhe-ying Liu, Cong-lin Wang, Lei Su, Yong-wen Feng*, Zhi-feng Liu*, Yong-ming Yao*. Thymosin a1 Therapy in Critically Ill Patients with COVID-19: a Multicenter Retrospective Cohort Study. International Immunopharmacology,2020(88)106873. (中国科学院二区,IF4.8)

科研团队

硕士研究生:黄佳佳、周志鹏、杨镇嘉、张晶晶、李达政、于佳敏、杨子龙(毕业)

获奖情况

2022年度深圳市科技进步二等奖