Ming Wu

Director of Preventive Healthcare and Hospital Infection Management Department

Master's Supervisor, Collaborative Supervisor for Postdoctoral Researchers


PI介绍

     

Director of Preventive Healthcare and Hospital Infection Management Department at Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), MD, Master's Supervisor, and Postdoctoral Collaborative Supervisor. With over 20 years of clinical experience in the management of sepsis, severe trauma, ARDS, AKI, SAP, MODS, proficient in techniques such as critical care ultrasound, fiberoptic bronchoscope lavage, plasma purification, and ECMO. Specializes in the comprehensive treatment of critically ill patients and multidrug-resistant infections. Has deep understanding in sepsis, critical coagulation disorders, AKI, CRRT, MODS in both basic and clinical research.

Currently serves as a standing member of the Life Support Group of the Intensive Care Rehabilitation Committee of the Chinese Association of Rehabilitation Medicine, member of the Thrombosis and Hemostasis Branch of the Chinese Research Hospital Association, member of the Critical Thrombosis and Hemostasis Professional Committee of the China Medical Education Association, standing member of the Plasma Therapy Professional Committee of the Guangdong Clinical Medicine Association, member of the Critical Illness Professional Committee of the Guangdong Pathophysiology Society, Vice Chairman of the Intensive Care Medicine Professional Committee of the Shenzhen Medical Association, Vice Chairman of the Blood Purification Professional Committee of the Shenzhen Health Management Association, among others.

Currently serves as a master's supervisor at Shenzhen University, Shantou University Medical College, Guangdong Medical University, Guangxi University of Chinese Medicine, having supervised 5 full-time master's students. Over the past five years, has led 6 provincial and municipal level funds, published over 50 academic papers, including 20 SCI papers as first or corresponding author, applied for 2 national invention patents and 2 utility model patents, granted 1 national invention patent and 1 utility model patent. Also serves as a reviewer for journals such as European Journal of Internal Medicine, Kidney and Blood Pressure Research, Platelets, Renal Failure, Frontiers in Medicine, etc.


科研项目

Shenzhen Municipal Science and Technology Innovation Committee, General Project, JCYJ20190806163603504, Mechanistic Study of Caveolin-1 Regulating Endoplasmic Reticulum Stress and Its Impact on Renal Tubular Ferroptosis in Severe Heat Stroke-Induced Renal Injury, August 2020 to July 2023, 100,000 RMB, ongoing, Principal Investigator;

Shenzhen Municipal Science and Technology Innovation Committee, General Project, JCYJ20170306091335008, Experimental Study on Baicalin Regulating Macrophage Mitochondrial Autophagy and Its Influence on Tubular Pyroptosis in Septic Mice, May 2017 to May 2020, 250,000 RMB, completed, Principal Investigator;

Guangdong Provincial High-Level Hospital Construction Project - Shenzhen Second People's Hospital, Clinical Research Project, 20193357003, Clinical Study on the Value of Renal Vascular Resistance Index in Predicting Acute Kidney Injury in Septic Patients, July 2019 to June 2022, 300,000 RMB, ongoing, Principal Investigator;

Guangdong Provincial High-Level Hospital Construction Project - Shenzhen Second People's Hospital, Clinical Research Project, 20203357014, Single-Center Randomized Double-Blind Controlled Trial of Berberine for the Treatment of Sepsis with Acute Gastrointestinal Injury, July 2020 to June 2023, 150,000 RMB, ongoing, Principal Investigator;

Shenzhen Municipal Health Commission, Clinical Research Project, SZLY2017007, RCT Study of Continuous Hemofiltration Adsorption Combined with Plasma Exchange for the Treatment of Sepsis Complicated with MODS, June 2017 to May 2020, 300,000 RMB, completed, Principal Investigator.


代表性成果

1)Yingyi Luan; Yan Liu; Xueyan Liu; Bao-jun Yu; Rong-ling Chen; Mian Peng; Di Ren; Hao-li Li; Lei Huang; Yong Liu; Jin-xiu Li; Yong-wen Feng; Ming Wu. Coronavirus disease 2019 (COVID-19) associated coagulopathy and its impact on outcomes in Shenzhen, China: A retrospective cohort study. Thrombosis Research, 2020, 195: 62-68.

2)Ziyun Shao, Yongwen Feng, Li Zhong, Qifeng Xie, Ming Lei; Zheying Liu; Conglin Wang, Jingjing Ji; Huiheng Liu, Zhengtao Gu; Zhongwei Hu, Lei Su, Ming Wu, Zhifeng Liu. Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID-19: a multicenter retrospective cohort study. Clinical & Translational Immunology, 2020, 9(e1192)

3)Ming Wu, Jing-jing Ji, Li Zhong, Zi-yun Shao, Qi-feng Xie, Zhe-ying Liu, Cong-lin Wang, Lei Su, Yong-wen Feng, Zhi-feng Liu, Yong-ming Yao. Thymosin a1 Therapy in Critically Ill Patients with COVID-19: a Multicenter Retrospective Cohort Study. International Immunopharmacology,2020(88)106873.

4)Jingjing Ji, Ming Wu, Li Zhong, Zheying Liu, Conglin Wan, Ziyun Shao, Qifeng Xie, Zhifeng Liu. Early, low-dose, short-term methylprednisolone decreased the mortality in critical COVID-19 patients: A multicenter retrospective cohort study. J Infect, 2021, 82(4):84-123.

5)Ying-yi Luan, Yan-Hong Chen, Xue Li, Zhi-Peng Zhou, Jia-Jia Huang, Zhen-Jia Yang, Jing-Jing Zhang, Ming Wu. Clinical characteristics and risk factors for critically ill patients with carbapenem-resistant Klebsiella pneumonia (CrKP): A cohort study from developing country. Infection and Drug Resistance,2021,14:5555-5562.

6)Ming Wu, Conglin Wang, Li Zhong, Zhifeng Liu. Serum myoglobin as predictor of acute kidney injury and 90-day mortality in patients with rhabdomyolysis after exertional heatstroke: an over 10-year intensive care survey, Int J Hyperthermia. 2022;39(1):446-454.

7)Ming Wu, Conglin Wang, Zheying Liu, Zhifeng Liu. Sequential Organ Failure Assessment score for Prediction of Mortality of Patients with Rhabdomyolysis Following Exertional Heatstroke:A Longitudinal Cohort Study in Southern China. Front Med, 2021, 9: 724319.

8)Ming Wu, Conglin Wang, Zheying Liu, Li Zhong, Baojun Yu, Biao Cheng, Zhifeng Liu. Clinical characteristics and risk factors associated with acute kidney injury inpatient with exertional heatstroke: an over 10-year intensive care survey. Front Med, 2021, 8: 678434.

9)Ming Wu, Ying-Yi Luan, Jun-Fu Lu, Haoli Li, Hai-Chao Zhan, Yan-Hong Chen, Fan Zhang, Yu-Yu Tian, Zi-Long Yang, Yong-Ming Yao, Yong-Wen Feng. Platelet Count as a New Biomarker for Acute Kidney Injury Induced by Haemorrhagic Shock. Platelets, 2020, 31, 1: 94-102.

10)Li Zhong, Ming Wu, Jingjing Ji, Conglin Wang, Zhifeng Liu. Association Between Platelet Levels on Admission and 90-day Mortality in Patients with Exertional Heatstroke, a 10 Years Cohort Study. Frontiers Med, 2021, 11: 716058.

11)Chuang Yuan, Ming Wu, Qicai Xiao, Wang Zhao, Hongli Li, Yanjun Zhong, Minyi Zhao, Cheng Li, Yang Li, Xinyu Yang. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis. Signal Transduction and Targeted Therapy, 2021,6(1):92

科研团队

Master's Students: Huang Jiajia, Zhou Zhipeng, Yang Zhenjia, Zhang Jingjing, Li Dazheng, Yu Jiamin, Yang Zilong (graduated).