Associate Director of Biobank, Shenzhen Second People's Hospital (Shenzhen University First Affiliated Hospital), PhD in Biochemistry and Molecular Biology. Principal Investigator of 1 National Natural Science Foundation of China (NSFC) Youth Project, 1 Guangdong Natural Science Foundation project, 1 Guangdong Medical Science Fund project, and 1 district-level project in Shenzhen. First author or corresponding author of over 10 research SCI papers published in journals such as Cell Death Disease, Frontier in Oncology, and Cancer Biology and Therapy.

September 2010 - July 2014: Jinan University, PhD

September 2007 - July 2010: Zunyi Medical University, Master's degree

September 2002 - June 2006: Heilongjiang University, Bachelor's degree

February 2021 - Present Deputy Director of the Biobank, Shenzhen Second People's Hospital;

July 2019 - January 2021 Full-time Researcher, Shenzhen Second People's Hospital;

June 2017 - June 2019 Postdoctoral Fellow, Shenzhen Second People's Hospital;

July 2014 - April 2017 Assistant Researcher, Shenzhen Institute of Otorhinolaryngology.

Research on the Mechanisms of Nasopharyngeal Carcinoma Metastasis

Engaged in the study of the pathogenesis of diseases related to the ear, nose, and throat, particularly focusing on the mechanisms of nasopharyngeal carcinoma metastasis and recurrence from the perspectives of the tumor microenvironment and epigenetics. This research aims to identify molecular targets related to nasopharyngeal carcinoma metastasis, providing a reliable basis for precision treatment of nasopharyngeal carcinoma.

Construction of Nasopharyngeal Carcinoma Research Models

Involved in the establishment of organoid models of nasopharyngeal carcinoma and the construction of humanized orthotopic PDX (patient-derived xenograft) mouse models for nasopharyngeal carcinoma.

National Natural Science Foundation of China (NSFC), Youth Project, 81902777, "Mechanistic Study of LncRNA MALAT1-ceRNA miR-5195 Regulating Sema3A in Nasopharyngeal Carcinoma Bone Metastasis," 2020/01-2022/12, 200,000 RMB, ongoing, Principal Investigator.

Guangdong Natural Science Foundation, Free Exploration Project, 2018A0303130295, "Study on the Role and Mechanism of Sema3A in Inhibiting Nasopharyngeal Carcinoma Bone Metastasis," 2018/05-2021/04, 100,000 RMB, completed, Principal Investigator.

Guangdong Medical Science and Technology Research Fund Project, A2015034, "Mechanistic Study of the New Allergen Profilin from Dust Mites Inducing TIM4 Expression in Dendritic Cells," 2015/07-2017/06, 10,000 RMB, completed, Principal Investigator.

Shenzhen Longgang District Science and Technology Plan Medical and Health Project, YLWS20150513154942700, "Mechanistic Study of Proteins Derived from Lung Epithelial Cells Regulating Dendritic Cell Function," 2015/09-2017/08, 30,000 RMB, completed, Principal Investigator.

1.Fan Xiaoqin #, Xie Xina#, Yang Ming, Wang Yujie, Wu Hanwei, Deng Tingting, Weng Xin, Wen Weiping, Nie Guohui. YBX3 Mediates the Metastasis of Nasopharyngeal Carcinoma via PI3K/AKT Signaling. Front Oncol 2021;11: 617621.

2.Xie Xina#, Lin Jiatian#, Fan Xiaoqin#, Zhong Yuantang, Chen Yequn, Liu Kaiqing, Ren Yonggang, Chen Xiangling, Lai Daihua, Li Xuyi, Li Zesong*, Tang Aifa*. LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription. Cell Death Dis 2021; 12: 201.

3.Fan Xiaoqin 1,2#, Wang YuJie 1,2#, Song Jian 1,2#, Wu Hanwei 1, Yang Ming 1, Lu Lu2, Weng Xin 3, Liu Lusha 4, Nie Guohui 1* The MDM2 inhibitor RG7388 leads to potent tumor inhibition via activation of p53 pathway in nasopharyngeal carinoma. Cancer biology and therapy.2019; 47: 116-122

4.Fan Xiaoqin#, Xiong Haiting#, Wei Jinmei, Gao Xuejuan, Feng Yuan, Liu Xiaohui, Zhang Gong, He Qinyu, Xu Jiake and Liu Langxia. Cytoplasmic hnRNPK interacts with GSK3beta and is essential for the osteoclastdifferentiation. Sci Rep 2015; 5: 17732.

5.Fan Xiaoqin #, Wei Jinmei #, Xiong Haiting, Liu Xiaohui, Benichou S, Gao Xuejuan and Liu Langxia. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol 2015; 47: 1485-1493.

6.Fan Xiaoqin, Liu Kaishan, Cui Wei, Huang Jiongmei, Wang Weina and Gao Yuan. Novel mechanism of intrarenal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats. Mol Med Rep 2014; 10: 2483-2488.

7.Jiang Congli #, Fan Xiaoqin #, Li Meng, Xing Peng, Liu Xiaoyu , Wu Yulan , Zhang Min *, Yang Pingchang*,  Liu Zhigang *. Characterization of Der f 29, a new allergen from dermatophagoides farinae. Am J Transl Res 2015; 7:1303-1313.

8.Wang Yujie, Wang Yuyang, Fan Xiaoqin, Song Jian, Wu Hanwei, Han Jinghong, Lu Lu, Weng Xin, Nie Guo hui. ABT-199-mediated inhibition of Bcl-2 as a potential therapeutic strategy for nasopharyngeal carcinoma. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1214-1220.

9.Gao Xuejuan, Feng Junxia, He Yujiao, Xu Fengmei, Fan Xiaoqin, Xiong Haiting, Liu Xiaohu, Sun Xuesong, He QinYu, Zhang Qong and Liu Langxia. hnRNPK inhibits GSK3beta Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep 2016; 6: 22999.

Our biobank has four dedicated staff members, three of whom have received pre-employment training and/or internal auditor qualifications for biobank quality standards, as well as certifications in human genetic resource management.

Director: Xie Ni (also serves as)

Deputy Director: Fan Xiaoqin

Biobank Dedicated Staff: Lu Jingxiao, Huo Qin, Sun Hong