Shenzhen Overseas High-level Talent (Peacock Program) Category B, one of Guangdong Province's 100 Innovative Doctoral and Postdoctoral Talents. Principal investigator of two General Projects of the National Natural Science Foundation of China (NSFC), a General Project of the Guangdong Natural Science Foundation, and projects funded by the Shenzhen Science and Technology Innovation Committee. Reviewer for the NSFC Key Cultivation Project, Youth Project, and General Projects of the Guangdong Natural Science Foundation. Published over 10 SCI papers as the first or corresponding author in journals such as Nature, eLIFE, Trends in Neurosciences, and J Extracell Vesicles, and acted as reviewer for several high-impact journals, positioned the Expert Committee Member of Basic Medicine on Aging, China Association of Gerontology and Geriatrics, and the Youth member of Chinese Society for Metabolic Biology, Biophysical Society of China.

Education

September 2000 – July 2004, Shanghai Jiao Tong University, Bachelor’s degree;

August 2004 – May 2009, University of Alabama at Birmingham, Ph.D.

Professional Experience

March 2009-January 2012，National Institutes of Health, National Cancer Institute of U.S., Postdoctoral Visiting FellowFebruary 2012-December 2017，Albert Einstein College of Medicine of U.S., Postdoctoral Researcher and Associate

January 2018 – Now，Shenzhen Institute of Translational Medicine, the First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Principal Investigator

Aging and Longevity Regulation, Age-related Diseases

Central regulation of systemic aging and longevity mechanisms

Mechanisms of brain and neural stem cell aging (genome stability, mitochondrial health)

Early inflammatory mechanisms and molecular diagnosis of Alzheimer’s disease

Metabolism and Immunity

Peripheral-central dialogue and metabolic diseases

Metabolic remodeling of immune cells and autoimmune diseases

1）Tang, Y.#, Zuniga-Hertz, J.#, Han, C., Yu, B., & Cai, D. Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice. eLife. 2020 Feb 21; 9:e52580.

2）Zhang G#, Li J#, Purkayastha S#, Tang Y#, Zhang H#, Yin Y, Li B, Gang L, Cai D. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 2013 May 9; 497(7448):211-6. (Article, Highlighted by News and Views in Nature, recognized by Faculty 1000, Top1% highly Cited Paper by Web of Science)

3）Yu, B.#; Tang, Y.#, Cai, D. Brain is an endocrine organ through secretion and nuclear transfer of parathymosin. Life Science Alliance. 2020 Oct 21;3(12):e202000917.

4）Xuan L, Cai Y, Luo J, Ding J, Yao G, Xiao X*, Tang Y*, Liang Z*. Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice. Cell Death Discovery. 2021 Accepted.

5）Tang, Y., Purkayastha, S., Cai, D. Hypothalamic Microinflammation: A Common Basis of Metabolic Syndrome and Aging. Trends in Neurosciences. 2015 Jan;38(1):36-44.

6）Li, J., Tang, Y., and Cai, D. IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012 Oct; 14(10):999-1012.

7）Tang Y#, Horikawa I#, Ajiro M#, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM & Harris CC. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene. 2013 May 30; 32(22):2792-8.

8）Tang, Y. and Cai, D. Hypothalamic inflammation and GnRH in aging development. Cell Cycle. 2013 Sep 1;12(17):2711-2.

9）Tang Y, Le L, Matthews QL, Han T, Wu H and Curiel DT. Derivation of a Triple Mosaic Adenovirus Based on Modification of the Minor Capsid Protein IX. Virology. 2008 Aug 1;377(2):391-400.

10）Tang Y, Han T, Everts M, Zhu ZB, Gillespie GY, Curiel DT, Wu H. Directing Adenovirus across the blood brain barrier via melanotransferrin (P97) transcytosis pathway. Gene Therapy. 2007 Mar;14(6):523-32.

Research Team

Postdoctoral Researchers: Yu Bin, Chen Nan, Gao Hong, Luo Jiao (Alumni), Li Xuan (Alumni), Cai You (Alumni)

Technician/Research Assistant: Ren Yi, Liu Jiabang (studying in graduate school)

Graduate Student: Chen Ziqin (graduated)