Hui Ding

Associate Researcher

PI介绍

Ph.D. candidate, Associate Researcher, C-Class Overseas High-Level Talent in Shenzhen, Head of General Affairs at Shenzhen Second People's Hospital/Shenzhen Institute of Translational Medicine, and Director of the Medical Innovation Center at Shenzhen Second People's Hospital. Specializes in nanozymes, nanobiomimetic drug delivery for early diagnosis and treatment of nasopharyngeal carcinoma, auditory protection in hearing loss, and nano-catalytic treatment of otitis media. Principal Investigator of several projects funded by the National Natural Science Foundation, Postdoctoral Special Funding, Guangdong Natural Science Foundation, and Shenzhen Science and Technology Innovation Commission. Published 15 papers in journals such as Signal Transduction and Targeted Therapy, Nano Today, ACS Nano, Nano Letters, Advanced Functional Materials, and Advanced Science. Holds 3 granted patents in China and contributed to drafting the national standard "Nanotechnology Terminology: Nanozymes."

教育背景

September 2013 - July 2017: Ph.D., University of Chinese Academy of Sciences/Washington State University, USA.

September 2010 - July 2013: Master's degree, Qilu University of Technology (Shandong Academy of Sciences), China.

September 2005 - July 2010: Bachelor's degree, Jining University, China.


工作经历

August 2019 - Present: Associate Researcher, Shenzhen Second People's Hospital.

August 2017 - July 2019: Postdoctoral Researcher, Shenzhen Second People's Hospital/Institute of Biophysics, Chinese Academy of Sciences.


研究方向和兴趣

Biomimetic Modification and Delivery of Nanomaterials

Early Screening and Treatment of Nasopharyngeal Carcinoma

Protection and Regenerative Repair of Auditory Damage

Nanocatalytic Treatment of Otitis Media


科研项目

National Natural Science Foundation of China - Young Scientists Fund Project, 82102205, Engineering Extracellular Vesicles of Engineered Antioxidant Nanomaterials for Synergistic Protection and Repair of Capillary Oxidative Damage, January 2022 - December 2024, 300,000 RMB, ongoing, Principal Investigator.

Open Project of National Key Laboratory of Tumor Chemical Genomics (jointly built by Province and Ministry), Application of Carbon-Based Nanozyme Biomimetic Materials in Biocatalytic Therapy for Nasopharyngeal Carcinoma, January 2019 - December 2019, 50,000 RMB, completed, Principal Investigator.

China Postdoctoral Science Foundation - Special Funding Project, 2019T120754, Application and Mechanism Exploration of Extracellular Vesicles Loaded with Nanozymes in Cancer Therapy, January 2018 - July 2019, 180,000 RMB, completed, Principal Investigator.

China Postdoctoral Science Foundation - General Project, 2018M633229, Red Blood Cell Membrane Biomimetic Nanozymes for Photothermal Synergistic Therapy in Nasopharyngeal Carcinoma Treatment, January 2018 - July 2019, 80,000 RMB, completed, Principal Investigator.

Natural Science Foundation of Guangdong Province - General Project, 2018A030310665, Novel Strategies for Nasopharyngeal Carcinoma Treatment: Biomimetic Membrane Nanozyme Catalytic Therapy, May 2018 - April 2021, 100,000 RMB, completed, Principal Investigator.

Shenzhen Knowledge Innovation Program - Basic Research Project, JCYJ20190806163814395, Leukocyte-Derived Extracellular Vesicles Loaded with Nanozymes for Regulating Tumor Microenvironment and Intratumoral Catalytic Synergistic Antitumor Therapy, April 2021 - April 2023, 100,000 RMB, ongoing, Principal Investigator.

National Natural Science Foundation Major Research Program - Study on New Strategies for Hearing Impairment Treatment, April 2022 - March 2026, ongoing, 3 million RMB, core participant.

National Key R&D Program - Research and Optimization of New Screening Technologies for Nasopharyngeal Carcinoma in High Incidence Areas, Project No. 2020YC1316900, October 2020 - September 2022, ongoing, 230,000 RMB, subproject core participant.

Shenzhen Science and Technology Innovation Commission - Key Laboratory Project, Shenzhen Key Laboratory of Nanozyme Translational Medicine in Cancer, April 2017 - April 2020, completed, 6 million RMB, core participant.

Shenzhen Three Major Engineering Projects - Chinese Academy of Sciences Academician Xiyun Yan's Nanoenzyme Tumor Transformation Project, June 2017 - April 2022, ongoing, 15 million RMB, core participant.


代表性成果

一、论文

1. Xiaojun Wang#, Hui Ding#, Zongyang Li, Yaonan Peng, Hui Tan, Changlong Wang, Guodong Huang, Weiping Li*, Guanghui Ma*, Wei Wei*, Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects, Signal transduction and targeted therapy, 2022,7:74.(IF:18.19)

2. Daji Wang#, Bin Zhang#, Hui Ding#, Dan Liu, Jianquan Xiang, Xuehui Chen, Zhongjun Li, Lei Yang, Hongxia Duan, Jiyan Zheng, Zheng Liu, Bing Jiang, Yang Liu, Ni Xie, Han Zhang, Kelong Fan*, Xiyun Yan* and Guohui Nie*. TiO2 Supported Single Ag Atoms Nanozyme for Elimination of SARS-CoV2. Nano Today, 2021,40:101243.(IF:20.72)

3. Hui Ding, Daji Wang, Haibing Huang, Xiaozhu Chen, Xiyun Yan*, Guohui Nie*, Minmin Liang*. Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy. Nano Research. 2021, 15:1554. (IF:8.897)

4. Hui Ding, Bing Hu, Daji Wang, Haibing Huang, Xiaozhu Chen, Xiyun Yan*, Guohui Nie*, Carbon-based nanozymes for biomedical applications. Nano Research. 2019, 14: 3. (IF:8.897)

5. Hui Ding, Yanjuan Cai, Lizeng Gao, Minmin Liang, Beiping Miao, Hanwei Wu, Yang Liu, Ni Xie, Aifa Tang, Kelong Fan*, Xiyun Yan* and Guohui Nie*. Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma. Nano letters. 2019, 19, 203-209. (IF:12.28)

6. Hui Ding, Yanjuan Cai, Jianxiong Chen, Tong Lu, Xiaojun Wang*, Guohui Nie*, Weiping Wen*. Cryodesiccation-driven crystallization preparation approach for Zinc(II)-phthalocyanine nanodots in cancer photodynamic therapy and photoacoustic imaging. Microchimica Acta 2019. 186(4):237.(IF:5,705)

7. Hui Ding, Fang Zhang, Chaochao Zhao, Yanlin Lv, Guanghui Ma*, Wei Wei* and Zhiyuan Tian*. Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response. ACS Applied Materials & Interfaces 2017, 9 (33):27396-27401.(IF:9.229)

8. Hui Ding, Yanlin Lv, Dezhi Ni, Jie Wang, Zhiyuan Tian*, Wei Wei* and Guanghui Ma*. Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer. Nanoscale 2015, 7 (21):9806-9815.(IF:7.790)

9. Dezhi Ni, Hui Ding, Shan Liu, Hua Yue, Yali Bao, Zhenhua Wang, Zhiguo Su, Wei Wei* and Guanghui Ma*. Superior intratumoral penetration of paclitaxel nanodots strengthens tumor restriction and metastasis prevention, Small 2015, 21:2518-2516. (IF:13.28)

10. Dezhi Ni, Shuang Qing, Hui Ding, Hua Yue, Di Yu, Shuang Wang, Nana Luo, Zhiguo Su, Wei Wei, and Guanghui Ma. Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer, Advance Science, 2017, 4(10):1700083. (IF:16.81)

二、授权专利

1. 阎锡蕴,丁辉,范克龙,杨明,纳米酶小体在催化光声成像中的应用,ZL201811454616.0(发明专利)

2. 丁辉,王晓君,王大吉, 李子威, 黄海冰, 刘洋, 聂国辉, 外泌体仿生修饰氧化铈纳米颗粒的递送体系及其在毛细胞中的应用,ZL2021108837921.1(发明专利)

3. 丁辉,王晓君,张俊英,聂国辉,一种纳米酶级联生物反应器及其制备方法和应用,ZL 202111544120.4(发明专利)

4. 丁辉,王晓君,黄海冰,蔡燕娟,一种耳鼻喉科用给药装置,ZL202022468520.9(实用新型专利)

获奖情况

1. 深圳市海外高层次C类人才奖励,2019年

2. 中国科学院宝洁奖学金,2016年

3. 国家留学基金委留学基金, 2015年

4. 中国教育部国家奖学金, 2012年