(1) The main research focus is on the mechanisms and translational research of ischemic stroke, including neurotransmitter receptor involvement in ischemic stroke mechanisms and translational aspects; endoplasmic reticulum stress and chemical genetics in stroke mechanisms and rehabilitation research; and the interplay between endoplasmic reticulum and mitochondria in ischemic stroke mechanisms. Specific studies include investigating the neurofunctional mechanisms of excitatory receptor NMDA and inhibitory receptor GABBAα5 in stroke. Completed preclinical evaluation of GABBA α5α small molecule drug S44819, followed by Phase II clinical evaluation in 92 hospitals across 14 countries with an investment of 25 million euros, registered under ClinicalTrials.gov Identifier: NCT02877615. Other research directions include Alzheimer's disease, spinal cord injury, cranial trauma, gliomas, and other brain injury-related disorders.

(2) Research directions also include tissue transparency and photoacoustic imaging (PAT), focusing on real-time dynamic imaging of brain vasculature and non-invasive imaging of gliomas.

National Natural Science Foundation of China, General Program, 82071471, Study on the Protective Role and Mechanism of Mfn2-mediated Neuronal Autophagy through PERK in Ischemic Stroke, January 2021 - December 2024, 550,000 RMB, ongoing, Principal Investigator;

Shenzhen Science and Technology Innovation Commission, Basic Research Program, Study on the Mechanism of AMPK Regulation of Neuronal Autophagy Mediated by ER Stress Kinase PERK in the Acute Phase of Ischemic Stroke, 120,000 RMB, July 1, 2021 - June 30, 2024.

1)Wang YC, Li X, Shen YT, Lyu JJ, Paschen W, Sheng HX, Yang W. PERK (Protein Kinase RNA-Like ER Kinase) branch of the unfolded protein response confers neuroprotection in ischemic stroke by suppressing protein synthesis. Stroke. 2020, 51(5):1570-1577.

2)Wang YC, Dzyubenko E, Sanchez-Mendoza EH, Sardari M, De Carvallo TS, Kaltwasser B, Doeppner TR, Machado P, Bassetti CL, Kleinschnitz C, Hermann DM. Post-acute delivery of GABAA α5 antagonist promotes post-ischemic neurological recovery and peri-infarct brain remodeling. Stroke. 2018, 49:2495-2503.

3) Wang YC, Sanchez-Mendoza EH, Doeppner TR, Hermann DM. Post-acute delivery of Memantine promotes   post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity. J Cereb Blood Flow Metab. 2017;37:980-993.

4) Wang YC^#, Galeffi F^#, Wang W, Li X, Lu LP, Sheng HX, Hoffmann U, Turner DA, Yang W. Chemogenetic-mediate acute inhibitionof excitatory neuron activity improve stroke outcome. 2020. Experimental Neurology, DOI:10.1016/j.expneurol. 2020.113206.

5)Liu YS, Wang XJ, Li XZ, Qiao SS, Huang GD, Hermann DM, Doeppner TR, Zeng ML, Liu W, Xu GL, Ren LJ, Zhang Y, Liu WL, Casals E, Li WP, Wang YC. A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke. ACS Appl. Mater.  Interfaces 2021,Sept 13, 39, 46213–46224.

Intern: Zou Lei

Master's Students:

Li Xiangzhuo (Graduated and stayed on)

Technicians and Research Assistants:

Ye Qinlian

Li Xiangzhuo