Lan Mu

full-time researcher

教育背景

2013.04 – 2016.10(Japan) Kyushu University
Cell Biology / PhD

2010.04 – 2013.03(Japan) Kyushu University
Cell Biology / Master's

2008.09 – 2010.03(Japan) Fukuoka International Language School
Japanese Language

2004.09 – 2008.07(China) Inner Mongolia Agricultural University
Animal Science / Bachelor's


工作经历

2021.04–Present(China) Shenzhen Second People's Hospital
Full-time Researcher

2018.03–2021.02(China) Tsinghua University
Postdoctoral Researcher

2016.10–2018.02(USA) University of Minnesota
Postdoctoral Researcher


研究方向和兴趣

Study the molecular mechanisms of skeletal muscle and myocardial fibrosis.

Research methods for direct reprogramming of mouse embryonic fibroblasts into muscle stem cells and their therapeutic effects on muscular dystrophy.

Investigate gene therapy methods and mechanisms for muscular dystrophy.

Study the influence and mechanisms of the skin regeneration microenvironment on the formation of skin appendages such as hair follicles.

Investigate the molecular biology mechanisms of malignant tumor initiation and development, and develop cancer treatment drugs and biological therapies based on DNA/peptides/antibodies/immune cells.

Have multiple research achievements ready for publication, including those related to skeletal muscle fibrosis, myocardial fibrosis, and tumor cell immunotherapy.


科研项目

Guangdong Provincial Key Laboratory of Nanomedicine Open Fund: Application of core-shell Fe3O4/Au magnetic nanoparticles in DNA sequence analysis, 2018.3-2020.2, ¥120,000 (Principal Investigator).

Guangdong Provincial Basic Research: Innovative therapeutic research on several new targets for tumors, 2018.2-2021.1, ¥3,000,000 (Participant).

Shenzhen Municipal Basic Research: Research on novel small molecule targeted therapies for malignant tumors, 2017.07-2020.12, ¥3,000,000 (Participant).

National Natural Science Foundation of China (NSFC) General Program: Study on the role and mechanism of fibrinogen and non-steroidal anti-inflammatory drugs in tumor metastasis, 2019.1-2019.12, ¥580,000 (Participant).

Shenzhen Municipal Basic Research Project: Role and mechanism of Chemerin in the browning of white adipose tissue in mice, 2017.07-2019.12, ¥500,000 (Participant).

NIH: Engineering iPSC-derived skeletal muscle and cells for transplantation, 2016.8-2018.6, $201,419 (Participant).

NIH: Genetically engineered muscle stem cell transplantation for muscular dystrophy, 2012.8-2017.7, $339,750 (Participant).

MEXT (Japan Ministry of Education, Culture, Sports, Science and Technology): Further understanding of resident myogenic stem satellite cell activation: inhibitory regulation by nitration of hepatocyte growth factor, Exploratory Research, 2014.4-2016.3, JPY¥3,900,000 (Participant).

MEXT: Understanding a novel mechanism to regulate myofiber types during muscle growth and regeneration, Scientific Research, 2013.4-2016.3, JPY¥19,760,000 (Participant).

MEXT: Cell-cell communications in developing skeletal muscle, Scientific Research, 2012.4-2015.3, JPY¥43,420,000 (Participant).


代表性成果

1.Qahar, M., Takuma, Y., Mizunoya, W., Tatsumi, R., Ikeuchi, Y. and Nakamura,M. Semaphorin 3A promotes activation of Pax7, Myf5, and MyoD through inhibition of emerin expression in activated satellite cells.

2.Mizunoya, W., Miyahara, H., Okamoto, S., Akahoshi, M., Suzuki, T., Qahar, M., et al. Improvement of Endurance Based on Muscle Fiber-Type Composition by Treatment with Dietary Apple Polyphenols in Rats.

3.Mizunoya, W., Okamoto, S., Qahar, M (Lan Mu)., Waga, T., Nakazato, K.,Ikeuchi, Y., Anderson, J. E., and Tatsumi, R., et al. Fast-to-slow fiber-type shift by dietary apple polyphenols in rats: impact of the low-dose supplementation. Animal Science Journal.

4.Wang C., Liu W., Nie Y., Qahar M., Horton HE., Yue F., Asakura A., Kuang S. Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts into Brown Adipocytes.

5.Lowe M, Lage J, Qahar M, Lohman M, Asakura A, Kikyo N. Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b. Cell Rep, 2018. 22(8): P. 2118-2132.