Researcher

Zhichao Li

Full-time Research Staff

Email：liz_hichao@126.com

PI介绍

Associate Researcher at Shenzhen Institute of Translational Medicine (Shenzhen Second People's Hospital), Class C Talent in Shenzhen Overseas High-level Talents Program, PhD in Biomedical Sciences from The Chinese University of Hong Kong, dedicated research professional. Principal investigator of National Natural Science Foundation of China (NSFC) Youth Fund, China Postdoctoral Science Foundation General Project, Guangdong Provincial Joint Fund for Basic and Applied Basic Research Youth Project, and Shenzhen Science and Technology Innovation Committee Basic Research Grant. First/corresponding author of multiple SCI papers published in journals such as Advanced Science, Nature Communications, Clinical and Translational Medicine, and iScience.

教育背景

August 2013 - November 2017, The Chinese University of Hong Kong, Faculty of Medicine, PhD September 2008 - June 2012, Xiangya School of Medicine, Central South University, School of Life Sciences and Technology, Bachelor's degree

工作经历

June 2021 to present, Translational Medicine Research Institute, Shenzhen Second People's Hospital, full-time researcher

January 2018 to May 2021, Sun Yat-sen University / Shenzhen Second People's Hospital, Postdoctoral researcher

研究方向和兴趣

Establishment and Application of Tumor Organoid Culture Systems

Establishment and optimization of tumor organoid culture systems derived from clinical tumor tissues to improve the success rate of tumor organoid cultures.

Utilization of tumor organoid models for testing anti-cancer drugs, investigating molecular mechanisms of tumor drug resistance, and developing corresponding therapeutic strategies.

科研项目

National Natural Science Foundation of China, Young Scientist Fund Project, 82103053, Establishment of upper urinary tract epithelial cancer organoid models and their application in personalized drug screening research, January 2022 to December 2024, 300,000 RMB, Principal Investigator, ongoing

China Postdoctoral Science Foundation, General Program, second-class funding, 2019M653215, Establishment and application of renal cancer organoid models, September 2019 to August 2021, 80,000 RMB, Principal Investigator, completed

Guangdong Basic and Applied Basic Research Foundation Provincial-Municipal Joint Fund, Youth Fund Project, 2020A1515110481, Establishment of upper urinary tract epithelial cancer organoid culture system and its application in anti-tumor drug screening, October 2020 to September 2023, 100,000 RMB, Principal Investigator, ongoing

Shenzhen Science and Technology Innovation Commission Basic Research Grant, JCYJ20210324102801003, Exploring the molecular mechanisms of resistance in upper urinary tract epithelial cancer using tumor organoid models and developing precision medicine strategies, October 2021 to October 2024, 150,000 RMB, Principal Investigator, ongoing

代表性成果

1. Li Z, Xu H, Gong Y, Chen W, Zhan Y, Yu L, Sun Y, Li A, He S, Guan B et al: Patient-Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening. Advanced science2021:e2103999.

2. Meng Z, Li Z, Xie M, Yu H, Jiang L, Yao X: TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis. Nature communications2022, 13(1):5728. (Co-first author)

3. Li Z, Xu H, Yu L, Wang J, Meng Q, Mei H, Cai Z, Chen W, Huang W: Patient-derived renal cell carcinoma organoids for personalized cancer therapy. Clin Transl Med2022, 12(7):e970.

4. Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F et al: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience2020, 23(8):101411.

5. Li Z, Yu L, Chen D, Meng Z, Chen W, Huang W: Protocol for generation of lung adenocarcinoma organoids from clinical samples. STAR Protocols2021, 2:100239.

6. Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA et al: TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology2018, 120:1-11.

7. Yu L, Li Z, Mei H, Li W, Chen D, Liu L, Zhang Z, Sun Y, Song F, Chen W et al: Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro. Clinical & translational immunology2021, 10(2):e1248. (Co-first author)

8. Qi Y, Li Z, Kong CW, Tang NL, Huang Y, Li RA, Yao X: Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology2015, 87:65-73. (Co-first author)