Ph.D. from the University of Chinese Academy of Sciences, postdoctoral research from Sun Yat-sen University, and Shenzhen Reserve Leading Talent. Currently an Associate Research Fellow at Shenzhen Second People's Hospital. The main research directions include the mechanisms of urinary system tumors and the construction of organoid models. He has hosted several projects including the National Natural Science Foundation of China, the Guangdong Natural Science Foundation, and the China Postdoctoral Science Foundation, and has been a key participant in one National Key Research and Development Program. He has published over 20 SCI papers in journals such as Advanced Science, Clinical Translational Medicine, Clinical Translational Immunology, and iScience, including 13 as the first or corresponding author. His research on bladder cancer-specific recognition and intervention received the Chinese Medical Youth Science and Technology Award.

Work Experience:

September 2015 - September 2017:Postdoctoral Researcher, Shenzhen Second People's Hospital, Supervisor: Dr. Cai Zhiming

October 2017 - December 2018:Assistant Research Fellow, Shenzhen Second People's Hospital

January 2019 - Present:Associate Research Fellow, Shenzhen Second People's Hospital

Mechanisms of Urinary System Tumorigenesis and Organoid Model Construction

1.Li ZC^#, Xu HB^#, Yu L^#, Wang J, Meng Q, Mei HB, Cai ZM, Chen W* and Huang WR*. Patient-derived renal cell carcinoma organoids for personalized cancer therapy. Clin Transl Med. 2022 Jul;12(7):e970.（共同通讯作者）

2.Li ZC^#, Xu HB^#, Gong YQ^#, Chen W^#, Zhan YH^#, Yu L, Sun YY, Li AY,  He SM, Guan B, Wu YC, Xiong GY, Fang D, He YH, Tang Q, Yao L, Hu Z, Mei HB, Zhisong He, Cai ZM, Guo YL, Li XS*, Zhou LQ* and Huang WR*. Patient-Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening. Adv Sci (Weinh). 2022 Feb;9(4):e2103999.(共同第一作者）

3.Yu L^#, Li ZC^#, Mei HB^#, Li WJ, Chen D, Liu Lisa, Zhang ZF, Sun YY, Song F, Chen W* and Huang WR*. Patient-derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR-T cells in vitro. Clin Transl Immunology. 2021 Jan 31;10(2):e1248.（共同通讯作者）

4.Li ZC^#, Qian YH^#, Li WJ^#, LiuLisa,Yu L, Liu X, Wu GD, Wang YY, Luo WB, Fang FY, Liu YC, Song F, Cai ZM, Chen W* and Huang WR*. Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020 Aug 21;23(8):101411.（共同通讯作者）

5.Wang ZQ^#, Li K^#, Chen W^#, Wang XX, Huang YK, Wang WM, Wu WJ, Cai ZM* and Huang WR*. Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules. Cell Mol Life Sci. 2020 Sep;77(17):3441-3452.(共同第一作者）

6.Li ZC, Yu L, Chen D,Meng ZY, Chen W* and Huang WR*. Protocol for generation of lung adenocarcinoma organoids from clinical samples. STAR Protoc. 2020 Dec 28;2(1):100239.（共同通讯作者）

7.Fan, J., He, Q., Jin, Z., Chen, W.*, and Huang, W.,* .A novel phosphoester-based cationic co-polymer nanocarrier delivers chimeric antigen receptor plasmid and exhibits anti-tumor effect. RSC Advanaces 2018, 8, 14975.(共同通讯作者)

8.Wang, Z., Zhou, Q., Li, A., Huang, W., Cai, Z.*,Chen, W*. Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer. Onco Targets Ther . (通讯作者)

9.Chen, W. ^#, Li, S.^#, Yu, H., Liu, X.,Huang, L., Wang, Q., Liu, H., Cui, Y., Tang, Y., & Wang, C. ER adaptor SCAP translocates and recruits IRF3 to perinuclear microsome induced by cytosolic microbial DNAs. PLoS pathogens 12(2):e1005462